Category Archives: Serrapeptase

The Butterfly Effect – Can the Butterfly Enzyme, Serrapeptase, Reduce Pain?

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Dear Pain Matters blog readers,

A couple of years ago, I sat next to an elderly lady in her 80’s during a flight between Los Angeles and San Francisco.  The woman told me that she used to have severe pain in both knees.

Then one day, the woman heard about serrapeptase for chronic pain.  After taking serrapeptase on a daily basis, she no longer has knee pain.  Because there were no side effects, she intended to take serrapeptase for the rest of her life.  Since no prescription was required, serrapeptase can be purchased online or in specialty health shops.

Struggling to keep up with her as I said goodbye (and I jog daily!), I took notice of her fast stride as she quickly walked out of the airport terminal.  She said she was in a big hurry as her friends were waiting for her at the cruise ship terminal!

After listening to her amazing story about serrapeptase’s beneficial effects on her knee pain and after watching her race out of the airport terminal, I decided to dedicate a blog post to her favourite pain medicine, serrapeptase.


So what exactly is serrapeptase?

The saliva of silkworms contains an enzyme called serrapeptase.  This enzyme is secreted by friendly bacteria called Serratia sp. E-15 that live in the intestines of silkworm.

The serrapeptase enzyme is sometimes called the silkworm-butterfly enzyme, silkworm enzyme or (my personal favourite) butterfly enzyme.  Scientifically, it may also be called serrapeptidase, serratiopeptidase, serratiapeptase, serralysin and serratia E-15 protease (the latter named after the bacteria from which it was first isolated).

Serrapeptase’s principal function is to break down and dissolve dead cocoon tissue during the silkworm’s transformation into a butterfly.  Serrapeptase plays a significant role in dissolving the non-living (‘avital’) proteins that make up the strong silk threads of the dead cocoon.

Serrapeptase’s strong protein-dissolving capabilities enables the silkworm-turned-butterfly to finally break loose from its old cocoon tissue (instead of remaining stuck in there forever).




Researchers found that when taken orally on an empty stomach, serrapeptase is absorbed by the small intestine where it enters the bloodstream.

Serrapeptase facilitates the breakdown of cellular debris and dead proteins within the bodily fluid and certain biofilms (via proteolysis).  It can dissolve proteins including fibrin in blood clots, arterial plaques and scar tissue.  Excess scar tissue near injury sites can often lead to pain, limited range of motion and nerve blockages.

NB Research is warranted whether serrapeptase’s deleterious effects on fibrin could alleviate certain painful conditions including endometriosis.

Serrapeptase reduces swelling, inflammation and pain as well as enhances tissue repair and regeneration.

The enzyme promotes the drainage of excess fluid including mucous via its anti-edemic effects hence improving sinusitis and other mucousal conditions.  It can reduce or eliminate cysts (e.g. breast cysts, ovarian cysts).

Serrapeptase does not target proteins in living tissue.  As such, it does not pose any risk to healthy tissue or cells.

There are no known side effects pertaining to serrapeptase intake (unlike non-steroidal anti-inflammatories that often causes gut wall damage and other adverse effects).



More details on serrapeptase are provided in the following video:


(1) Amba Carrington 

Amba Carrington (28) suffered severe stabbing pain in her lower back following a motorbike accident 6 years earlier.  One day, Amba’s doctor suggested that Amba try serrapeptase (SP-Zyme).  Six (6) weeks later, Amba was completely pain-free.  Quoting Amba:

‘For years, I took strong prescription painkillers and had injections to relax my back muscles, but nothing cut out the pain effectively … I was unable to drive, walk long distances or exercise. The pain was crippling and wiped me of energy. It was horrible – I felt like an old woman.’

‘… after a few days, I felt my back pain easing off, and after ten days, it had gone completely. I can barely believe it, but today I am free from chronic pain.’

(2) Jann Barry

A patient named Jann suffered ongoing pain and stiffness due to rheumatic arthritis (RA)  diagnosed 2 years earlier.  

Jann started taking Serraenzyme (250,000IU) 8 months ago.  His dose during the first 2 months was 6×250,00IU daily.  This was decreased to 4×250,000IU/day during the next 2 months, and further reduced to 2×250,000IU/day for the last 4 months.

Quoting Jann,

‘The change in me is nothing short of miraculous. Apart from a bit or morning stiffness, I have no pain what so ever.  A fungal infection in both my big toenails, which [until now had] responded to nothing … , disappeared within the first month.  My nails, which spent 80 years splitting, peeling and breaking, are now like steel tallons – well almost! I actually have to file them down every day.

I now have 5 friends on Serraenzyme and I’ll be on it for the rest of my life.’

(3) Other Serrapeptase Stories

Chronic Pain Relief – Serrapeptase Testimonial Video (3-minutes)

This patient’s back pain as well as neck and shoulders pain is now ‘dramatically reduced … feels better’ (quoting patient) after only 1 week of serrapeptase (refer to 1:14 minutes on).

Benefits of Serrapeptase – 3 Amazing Serrapeptase Testimonial Videos (3-minutes)


Given its anti-inflammatory, anti-edemic, proteolytic and fibrinolytic effects, serrapeptase is increasingly being considered as a safer alternative than non-steroidal anti-inflammatories by patients suffering from pain and inflammation.

Serrapeptase can reduce swelling and fluid (edema) at wound and infection sites as well as decrease mucus and other secretions at mucosal membranes (e.g., ear, nose, throat).

Athletes often take serrapeptase as a supplement to treat injuries and prevent swelling after surgery.

Subject to medical supervision, pain patients including patients with arthritis and localised edema are encouraged to try serrapeptase for pain relief (given very little or nil side effects).

Could the silkworm become one of humankind’s new best friends??

Sabina Walker

Blogger, Pain Matters (in WordPress)

PS Please feel free to share your personal experience with serrapeptase via this blog. 



(1) Tiwari. The role of serratiopeptidase in the resolution of inflammation. Asian Journal of Pharmaceutical Sciences (May 2017); 12(3): 209-215.

(2) Al-Khateeb and Nusair. Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars. Int J Oral Maxillofac Surg. (March 2008); 37(3): 264-8.

(3) Sannino et al. Combination therapy including serratiopeptidase improves outcomes of mechanical-antibiotic treatment of periimplantitis. Int J Immunopathol Pharmacol (2013); 26(3): 825-831.

(4) Mecikoglu et al. The effect of proteolytic enzyme serratiopeptidase in the treatment of experimental implant-related infection. J Bone Joint Surg Am (2006); 88(6): 1208-1214.




Many science papers are provided in this link.


(1) Amba Carrington – Lower Back Pain Patient 

Stephens, Anastasia. How silkworms can end back pain. Daily Mail.

(2) Jann Barry – Back Pain Patient

(3) Lea Verity – Tempero-Mandibular Joint Patient (not described in blog) 

Hilary Freeman speaks to Lea Verity whose life has been transformed by Serrapeptase. Daily Express (5 February 2002 – extracts).


(1) Tehrani, Mona. Das Schmetterlings-Enzym: So gut ist Serrapeptase für deine Gesundheit. Elle ().

(2)  Serrapeptase